Difference Between Wellbutrin SR and Wellbutrin XL
Wellbutrin SR vs Wellbutrin XL
Feeling sad is natural for most people especially when there is good reason to be. Some things might not go the way we originally planned them. It’s natural to feel sad, but when sadness becomes extreme and getting back up on your feet seems to be a difficult thing, it could become a real problem. If sadness persists even after a week and is interfering with your ability to socialize or mingle with other people and have fun, then it’s likely that you are going through depression. Fortunately, depression is not the end of everything; it can be treated. Various treatment methods are available, and this includes psychotherapy, group discussions, and even the use of medications. Several antidepressants are now available and have been proven effective in making symptoms of depression disappear. One of the medications prescribed for depression is Buproprion, under the trade name Wellbutrin. Wellbutrin is available in XL and SR formulations, but what is the difference between the two?
Wellbutrin contains the active ingredient Bupropion. Bupropion is an antidepressant and, at the same time, a smoking cessation aid. It works by increasing the levels of certain chemicals in the brain which are responsible for pleasurable feelings. With a proper dosing regimen, the drug is effective in treating the condition. The risk of developing serious side effects is low, but if the drug is misused and abused, potentially life-threatening effects may occur.
Wellbutrin is the antidepressant formulation of Bupropion while Zyban is the formulation used to help people quit smoking. Bupropion is available in XL and SR formulations. Both formulations are called time-controlled release formulations. “XL” attached to the end of the drug name stands for “extended release” while “SR” means “sustained release.”
Wellbutrin SR means that the dose of Bupropion is slowly released into the body throughout the day with the goal of maintaining a constant drug concentration in the bloodstream. Wellbutrin XL releases the dose for an extended period of time in a day. The SR formulation is slowly released in 12 hours while the XL doses are released for a period of 24 hours.
The dosing recommendations for both Wellbutrin formulations also differ since both drug delivery systems are controlled by time. Wellbutrin SR is initially given as 150mg once daily, and after 4 days the dose can be increased to twice daily to achieve a constant drug concentration in the blood. On the other hand, the extended release form is usually given once a day since the dose is being released in a 24-hour time frame.
There are benefits to using time-release medications like Wellbutrin XL and SR. These include:
- Uniform release of the drug dose in the body.
- Minimized side effects.
- And better patient compliance.
These benefits are common to both formulations, but more benefit is obtained through Wellbutrin XL.
The most obvious advantage of the extended release formulation is the reduced frequency of drug intake which will result in better patient compliance. Patients find it inconvenient to have to take the drug at certain periods of time, especially for such drugs like Wellbutrin where it needs to be taken for a certain period of time. There may always be instances where a patient will forget a dose and will simply skip it which can affect the overall effectiveness of the drug regimen.
In the case of Wellbutrin, the XL formulation is taken only once a day compared to Wellbutrin SR where it is taken twice daily. Of course, the more convenient formulation will be the one where the patient will have a reduced frequency of popping medications. In addition, you don’t need to take Wellbutrin XL as often so there would be fewer side effects. When using these kinds of medications, always consult your doctor.
Summary:
- Wellbutrin XL is the extended release formulation while Wellbutrin SR is the sustained release form.
- Both drugs are time-controlled release formulations.
- The Wellbutrin SR dose is released in a 12-hour period while the Wellbutrin XL dose is released in a 24-hour period.
- Both drugs produce, more or less, the same side effects but to a lesser extent with Wellbutrin XL.
- The dose for Wellbutrin XL is once daily, while the Wellbutrin SR dose is usually taken twice a day.
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I searched many responses to my question regarding prescription differences between Bupropion XL and SR and didn’t get a clear and thorough answer until I hit this website. This posting was very helpful. Thank you!
Thank you, Anna. This was very helpful.
I never remember this difference
SR is slow release and taken every 12 hours.
XL is extended release taken once a day
Thank you sooo much ! I just switched from bupropion sr to Xl and this article is answered all of my questions !
How have you felt since switching? Any noticeable differences? Any side effects ??
Thinking of doing the same. Thanks!
I feel a lot more depressed but our insurance company, United Healthcare wouldn’t authorize the 450mg of purple SR because I took two in morning one in afternoon and it amounted to 450mg. NOW I’ve been switched to the 450 XL with was $38.00 vs $4.00 copay prior and I’ve been so depressed like its making me feel worse.
I normally 300mg of the XL, but ran out. I took 150 mg SR for two days, exactly 12 hours apart. I felt noticeably better during the day, but I had a very hard time sleeping both nights. I just bought a 90 day supply of the 300 mg XL, but I am going to talk to my doctor about changing my regime. The clarity of mood I experienced on the 150 mg SR was quite pronounced and I had two very productive and cheerful days.
Did you have insomnia and memory fogginess from the XL.
My daughter took 150 XL for a year with no side effects but recently was struggling more & so the doctor started her on 300 XL. 3-4 days later she had a Grand Mal seizure. They are 99% sure it was caused by raising her dose & it was just to much for her small body. The doctor is slowly weaning her off of this medication & she is not to take it again. My warning is to be careful while taking this medication. Do things slowly while increasing your dosage or decreasing. If you quit cold turkey there is a possibility of seizure as well. Good luck & Be safe!
Thank you your website explained it very well. There is no other website that explained it the way yours did. The l you again
I agree with other respondents that this article explain the difference between the SR and XL very well. I’m also interested to know if the XL has caused sleep disturbances for anyone.
Hey Betsy. I have been taking the XL for a while now and I have not had any sleep problems related to this drug. In fact, it has helped me lose weight which I needed. It took a little while to get in my system good and to start working but the last 3 months I have lost 33 lbs. Hope this has helped you.
Wow Lori! That is great news. I’m on the XL now and it is working well for me for sustained energy throughout the day. I need to lose weight from being on Depakote so I’m thrilled that you’ve had such great success in that area. I’m off Depakote and look forward to weight loss. Thank you so much.
Lori, were you on the SR prior to starting the XL?
Hello,
How many mg are you taking daily?
That’s good news! Congratulations! My doctor has prescribed the XL 150 today and after reading all the side effects, it’s got me a bit nervous. I need to take it for weight loss. How did this medicine make you feel. I am 56, female and need to lose 50-80lbs.
My current doctor switched me from Prozac, which I was taking for over 5 yrs., and was causing me to feel so bla and useless and tired, to Bupropion 300XL once a day. It has been a miracle for me! Not only do I feel great and like my old good self, but my joint pain has mostly disappeared….and I am 70 yrs old!
To answer your question about sleep, it has not disturbed my sleep at all and in fact sleep seems to have improved, plus I wake up on my own and feel good!!! As I said, it was a miracle for me.
Good luck!!
Hi Dia I’m 71 and on 150 xl Wellbutrin …. I have Hashimoto Thyroid and isn’t under control so I was thinking of asking my doctor if I should up my Wellbutrin. I have NO energy, never leave home unless it’s doctor appointment, can’t remember last time I had fun or laught …. I just want my life back so I can enjoy life again …. 300 seems like a lot did it make you nervous, anxiety etc. thank you for listening. God bless you. ❤️
Yes, I have definitely had trouble with sleeping since I recently started taking welbutrin 150XL
I was relieved reading your post…to hear my problem was not just myself! I am actually going to speak with my Dr. about switching to welbutrin 12hr.SR instead of the wellbutrin 24hr. XL.
I’m hoping that the
12hr. SR
will naturally have less interference with my sleep than this 24hr. XL. I hope this post was a bit helpful.
TheXL was partly to blame for my shakiness and agitation
I just switched from XL to SR and seems to work better for me
Remember though that we’re all different
I agree the xl was to strong for me and the sr seems to work better, as you say we are all different ,
Hello Betsy, I have had sleep disturbances with 150 mg of the XL. Vivid dreams and nightmares every night. And I have way too much energy in the evening, laziness during the day.My doctor has switched me to the SR 100mg 2x per day to see if that will make a difference. She said I may be metabolizing the XL too slowly. I was also taking 100 mg of seroquel and have been raised to 150 now to try and combat the sleep issues that wellbutrin has caused. She said she has never heard of anyone having this problem but sees how it is possible. My medication was adjusted today, the date that I am responding to your post.
seroquil is the worst medication I ever took, well next to lithium. seroquil made me gain weight and my ass dragged all day until about 6pm. I don’t like being drugged out all day. get off seroquil it’s bad. I now take geodon and it’s great.
I was taking it at night and stayed awake. I started it in the am and it is better.
Yes, XL seemed to reduce my ability to get a good night’s sleep, big time. I take SR and sleep better. Note: I love how bupropion makes me feel better. My pharmacist said that SR relies on a different way of releasing the med in your body/brain than the XL does. Something to do with “clumps” vs. little round granules. Btw. Also I get a pronounced allergic reaction to brand-name Wellbutrin – but no problem when taking generic SR. Go figure!
Yes, I had big trouble sleeping when I took the XL, even a small dose! I was so exhausted from lack of rest . So I take Bupropion SR once a day (in the morning of course!)
My husband takes the XL .. he sleeps like a baby, if he is over tired however he can wake up and talk in his sleep, he is more restless but other than that its great .
I have recently switched from SL to XL. I was only taking SL once a day and would have a big dip around 3pm. Did not know about taking it twice a day. So I switched to XL and loved it. Until I started having sleep problems. I can’t stay asleep. I have enough energy to get through the day now but sleep disturbances. Don’t know what to do so I made an appointment with my Dr to discuss.
I’m wondering if anyone has had success taking the XL and SR together in the morning. The XL has worked well for me for the past couple of years but I’m finding that I have plateaued and need an extra boost. Is it possible to take a smaller dose of the SR in addition to the XL?
I was on the 300 XL in the morning and 150 SR in the afternoon/evening. So it’s possible.
My dr switched me to 2 SR 150 in the morning and 1 150 SR in the afternoon but I don’t really like it. I find it wears off too quick for me.
This is my question too
Hello,
Does anyone have any advice? I have been taking Fluoxetine (generic of Prozac) for three years with terrible side effects (muscle and joint pain, fatigue, low energy, feeling cold, weight gain). My doctor suggested Wellbutrin and I took my first 150mg XL dose. I felt great. I immediately had energy to exercise (didn’t on Fluoxetine, had increased appetite so put on 22 lbs). On Wellbutrin, I did not feel hungry at all. However, when it came to sleeping, I couldn’t (I am a long-term insomniac). So I bit the pill in half the next morning, and took half before going to work. Only when I read the package insert this evening, did I see you are not supposed to split them. I am thinking of going on to 75 mg Sustained Release (SR), because at least that wears off after 12 hours, or taking a 50mg immediate release one twice a day. Has anyone any suggestions? I loved this medication – feel great on it except for the sleeping part.
If you cant sleep just have yout dose lowered to where you can.
wellbutrin is a great drug. it helps u lose weight and originally it was used to quit smoking and weight loss. I was taking 200mg in the am and 200mg in the afternoon. it was the sr. but I asked to go on the co 300mg in morning. I like it better. you just have to give it a chance
So i have been taking 2 xl 150 every am and now i pick up sr 150 as my new dr prescribed this…should i still take 2 in the am?
This is the best explanation I’ve found, thank you. Any idea if xl is equally as effective for smoking sensation vs sr or the original one?
yes
Why the doctor presribe for some patients sr and for others er ?
I have been on both XL & SR, I do better with XL.. The SR makes me feel like I’m throw up drunk for some reason, maybe it’s going into my system too fast on SR since it’s 150mg SR going in my system over 12 hours instead of 24 hours
Thanks for this simple & informative write up. I’ve been off & on antidepressants for about 5 years that began when I was diagnosed with relapsing/remitting multiple sclerosis. Of course the depression hit me hard at first, mainly because I had a 2 year old daughter at the time and was terrified of the unknowns. Pain management doctors kept me on antidepressants in order to hopefully control some of my various pains and random symptoms. I was on a ridiculous amount of pain pills and nerve blockers and everything else you can imagine. The side effects from some of these drugs (I’m looking at YOU, Cymbalta) were FAR worse than any other issue I had experienced with my diseases. It was horrible!! I ended up being prescribed even MORE pills in order to treat the stupid Cymbalta withdrawals! (Including Celexa- another antidepressant. And anti-convulsants) Finally I was able to get down to .25 of a milligram and felt well enough to jump off from there. YES, ONE FOURTH OF A MILLIGRAM, folks! It was really scary realizing just how horribly horrible that drug had been effecting me, my body, my weight, my emotional numbness to things I should’ve been enjoying with my daughter & family, my job…my overall health and well being.
(pardon my rambling, but you get the point: I hated Cymbalta and Cymbalta hated me. I’m a huge anti-Cymbalta advocate)
Anyway now I’m down to only 2 pills a day (one’s birth control to keep my hormones in check, and that is a huge help when it comes to pain control, my pain & flares are very hormonally influenced.) I had been antidepressant free for a while, maybe a year, but I wasn’t motivated. Always in pain & tired. My dad passed away in April last year, and that sent me into a horrible depression. Luckily I found a great doctor (Dr. Clayton Royder – Oklahoma City) and he slowly titrated my dose up to the 300 mg of Bupropion XL I’m on now. I wrote a novel to finally ask this one tiny question…i have some of the
Can wellbutrin help you stop smoking?
Yes! It really helps. And not just smoking. It seems to have put all my bad habits and check. It really helped. I mAt Sports Clips in Boca losing it on the lady demolishing my sons head.
Praying I keep perspective.an big time. I still take it. It also really curbs your appetite in the beginning, which for me was a good thing. Best of luck to you.
Yes it is also prescribed for people who wants to stop smoking
yes…chantix is the best way to quit smoking
I’ve been on BurpropionXL 150 for almost a year and my weight just keeps going up. I think I could sleep twenty fours a day! I feel foggy most of the day. My thyroid results are all normal. Most people have the opposite effect. Any thoughts on this?
I am having the same problem. Been o. Wellbutrin xl 150mg for two months I eat more and smoke more. I was wondering if increasing to 300mg would help!
If you are taking a generic bupropion, try changing to a different one. I had the same drowsy sleepy effect until I switched generics.
I’m going through the same. Completely depleted of any energy during day. Sleepy …like pregnancy sleepy. I never nap, in fact I have too much to do so I can’t nap, but I’m forced to while taking XL. I started on SR and it seemed better. After a month, doctor put me on xL. I’m off of it now for the past 4 days, and taking SR. Let’s see if my irritability dissappear’s and sleepiness diminishes as well!
Interesting. I’ve been losing weight. You should try Lexapro. That made me gain weight. But maybe we have the opposite effects
Do SR instead of XL to see if makes a difference with your body. I also did DNA swab to see which antidepressant works best for me.
I, too, feel foggy and only have moments of energy; definitely not enough to function normally. Was on 300 SR, then 300 XL, & now the max dose of 450. Wondering why I”m experiencing such a different reaction. Going to talk to my doctor about starting the SR again. Hope things get better for both of us, Glenda.
Has anyone had cluster-like or migraine-like headaches from the XL? I seemed to, then went to the SR, and seem to be fine. I’m wondering if it was indeed the XL, or something else I wasn’t accounting for. Anyone else?
I am having the same problem. Been o. Wellbutrin xl 150mg for two months I eat more and smoke more. I was wondering if increasing to 300mg would help!
Which dosage contains largest and/or most effective application of bupropion without sleep or weight effects? SR for several years has not caused problems in these areas.
Taking generic wellbutrin xl 450mg for 6 months. .The metal taste won’t go away. Have good result . but can’t take this constant taste. Just won’t go away !
I have been in the SR 150mg x2 a day for 3 weeks. I also develope a horrible taste, in the a.m. after awaking is horrible! I’ve also notice is worse if I eat certain things like ice cream or spicy. I’ve requested to be switched to 300xl and hope it helps. Otherwise I’m asking for something else.
Anyone else with this bad mouth taste?
I was in the XL 450 a day due to an absorption problem, was on it for years. It seemed to stop working. My dr now has me on the quick release 3x’s a day 150 each time but now it seems to give me headaches. Not affecting my sleep as I have insomnia and on sleep RX.
Does anyone else take such I high dose and if so does it give you headaches? I’m wondering if because it’s quick release compared to the XL it’s causing the headaches? Thank youb
Yes. I took 450mg xl and found it gave me massive headaches. I had been on 300mg for years and felt it had plateaued. I had to go back to 300mg, I couldn’t take it. I’ve yaken 450mg of SR and it gave me facial twitches and anger outbursts. I love wellbutrin, lost weight but I just still feel blah. We added Celexa recently but I have a chronic yawn!
Hello, my doctor has me taking 150mg XL twice a day. Should this be a concern since it is in fact the XL, not the SR, and I am taking it twice a day?
Any feedback at all will be helpful and appreciated. Thx!
I have been taking Wellbutrin XL 300mg and my mood is mostly good. However, I am having a hard time eating. I don’t feel like eating even if my stomach is physically hungry. It’s becoming a challenge
I’ve been on 150sr twice a day for a long time. A lot of times I don’t remember to take the second dose. I’m going to doc this morning. I’m going to ask to switch to xl. I don’t know if I should ask for 300xl or start lower. I just no longer have any energy. I also have a severe sweating problem. All the blood work doesn’t show any reason why I’m like this. This has been going on for years. Does anyone else experience sweating. I’ve been in this drug for about 8 years and the sweating has been going on for about 3 years.
I was put on Bupropion SR 150 twice a day for about six months, unfortunately my Doctor Passed Away ( so sadly missed ) I found a new Doctor and my prescription was changed to Bupropion XL 150 my pharmacy was out of this med so I’m waiting. I have no idea what to expect! I have also had metallic taste in my mouth, I have asked Doctors Why They Look At Me And Shrug, Really Obviously The Bupropion SR Must Have Done It . Thanks
I was prescribed 150 mg SR 5 months ago after trying a few SSRI’s and finding they just don’t work for me. I am doing much better on Wellbutrin, but still had some very bad nights. My Dr. increased my dose to 300mg SR about 2 months ago, but still only once a day and now last week my psychiatrist added some ritalin in there too. After reading more about bupropion and the risk of seizures, I’m worried that this is a really dangerous experiment especially with my doctor knowing I still drink (I’m trying to stop). I fear he may have forgotten that I was on the SR and not the XL, and just changed the number without really looking it over. I won’t be able to get an appointment with him for at least 2 weeks with the Christmas holidays upon us. I called my pharmacist who couldn’t advise me to change the way I’m taking the drug without my doctors approval.
Basically the point of this comment turned question is to see if I should continue to take the 2 x 150mg SR once daily and just hope I don’t have a seizure?, or with the information I’ve gathered on these sites should I divide the dosage to 150 SR twice a day as a safety measure until I can meet with either my GP or Psychiatrist…
I’ve been taking the bupropion xl 150 2xday. I switched to mail same CVS they sent bupropion 150 2xday. I almost had a nervous breakdown I was never so scared in my life I thought I was losing my mind horrible. Been on xl for many yrs no problem ne re was so scared in my whole life still dont feel completely right
I was taking bupropion Sr….I had to stop. I was having dreams that was so vivid that I thought they were real…. I’d go through the day a wreck…it all seemed so real……I don’t take anything now… I’m managing as I can.
Has anyone experienced any tremors taking Wellbutrin XL?
Do any of you take wellbutrin for anxiety? If so has it helped?
Thank you
I take Wellbutrin XL 300mg once in the morning, and it has helped my depression, but my anxiety even more so! But the weird thing is, it was most effective the first day I took it! Why could that be??
Can someone help clarify my dosage from sl to xl please ?!? I feel so silly not understanding this. I have been happily on bupropion sr 150mg twice daily. My dr unexpectedly switched me to XL 150. which I take once in the am. I have been teary, down etc but coincided with life stressor. My pharmacist confirmed he thought the equivalent dose would be XL 300 mg NOT the 150 she has me on. She denied this to be true. Ugh !! Can anyone help me know if 150mg sr twice daily is equivalent to 150mg Xl once daily ? Thank you !
Stephanie,
1st: I’m sorry you’re going through this. Ugh is right. Next: I’m not a doctor, so I’m going to speak from my own experience & my own information search. I vote that the pharmacist is correct! (Now what are you supposed to do?!?)
You’re now getting approx. 6.25 mg average per hour of med. in your blood serum; before you had approx. 12.5 mg average per hour. If I understand your question correctly. Read on…
Can you call the drug company’s helpline? See more suggestions, below.
My doctor switched me from 300 SR/day to 300 XL/per day, saying this was equivalent. The pharmacist agreed. I agree.
So, about you & your meds …
Before, you had 150 mg, spread out, released to span each 12-hour period. 150 mg ÷ 12 hrs = 12.5 mgs per hour, average. _Each_ 12 hour time period. Two periods per 24 hour day.
Now, you have 150 mg, spread out, spanning a 24 hour period. 150 mg ÷ 24 hrs = 6.25 mgs per hour, on average per hour. Per 24-hour cycle … “Day”.
Also: There are graphs, based on lab studies, that show the rising and descending levels of the med in people’s bloodstream… Yes, it takes a while (usually a couple/few hours) for the med to go up to its highest level, and then, a steady for a few hours, then a while to taper down to a low level, each time a person takes the dose of med. These curves on the graph tend to overlap. So… Your average per hour _isn’t really_ the same as the blood serum quantity you have per hour, unless you’ve been on the med for several weeks -and- if you are a typical metabolizer.
By the way- the curved line on the graph for XL covers approx. a 24-28 hour time period. (The low-level phases overlap each other, eventually adding up, eventually evening out, but that doesn’t change the 6.25 mg _average_ per hour!)
Can you call the drug company consumer helpline? Can the pharmacist email or call a rep at the drug company regarding this issue? Would the doctor do the same? Sometimes a doctor is not a math person, sometimes they listen to their drug rep, who got the math wrong. Holy cow.
Meanwhile, can you get a…
2nd opinion from another doctor? Can you get …
Someone to assist/advocate with you & for you quickly, given you’re weepy & down lately?
… Can you get a memo/email from the pharmacist to the doctor?
Or from the drug company to the doctor?
Please follow up, and if possible let me know what happens next. Hoping for a nice resolution to this. If you can, use whatever methods you’ve learned to keep your chin up, your spirits up, and your stress down. Wishing you peace, balance & progress.
– Elizabeth Keeling
You can’t judge the good or the bad in the first few days. My first few days with Wellbutrin sr were amazing I was very happy I found a way to move forward in life and then after about 6 days it stoped working that way. On the other hand a few weeks after I started the extra insomnia went away. Then when I went to two daily (150mg each) the extra insomnia came back , now months after I started I think I’m actually falling asleep faster.
I don’t think Wellbutrin sr is doing much for me , I’m just happy my weight is no longer increasing from my other antidepressant.
I always took lunesta for sleep but at the beggining of Wellbutrin even that didn’t help.
I suffer from fatigue and I don’t think that wellbutrin is helping me , is sad because I was happy about an antidepressant that doesn’t make you gain weight.
I noticed that since I started going to the gym has become much harder I used to be addicted to gym.
I’m wondering if the doctor will suggest changing to xl or if he will change my medication to another one. ( perhaps cymbalta which gave me energy in past)
Can xl help if sr didn’t ?
Someone asked why a dr would prescribe sr over xl? By me the concern was making my insomnia worst
Hi i hope soeomo e can help me im on zoloft 150 mg and just stsrted taking wellbutri 150 xl 150…im not feeling much affect and i feel the worst in yhe am…why id that…i really hope it works for me..
I was on Wellbutrin XL 150 mg, increased some time ago to 300mg.
I understand is supposed to be released over a longer period of time but even so, feel like the release mechanism isn’t even.
Do you think it makes sense to switch it to 150XL twice a day?
Checked with my doctor who says its OK but wanted to know if that would be a good idea? Any negative implications?
Xl is released slowly the entire day , sr does it faster so usually people take sr twice a day. Originally it was only available as a twice a day pill but people don’t like taking meds twice a day , many depress patients forget. They cake out with a once a day dose which is the xl. I asked my psychiatrist if one is more helpful for depression than the other one he said exact same in that regard. Some people like sr that way if they take early enough they won’t have trouble sleeping as the medication kind of gets out of your system in 12 hours whereas xl is in the entire day.. ( of course meds take days to get out of system but most of it )
I think you can take your dosage in whichever way you want , you can mix sr and xl as long as the added dosage is the one prescribed. As far as your question on taking xl twice a day , you might experience insomnia but no way to know until you try. You can also try one xl in morning and one sr 12 hrs before bedtime.. some people can take either one at any time and sleep soundly. In general xl is more gentle in as far as how your feel less medicated , is like having coffee slowly come out of a capsule vs sr been like having all your caffeine in one shot that’s my analogy some people would love sr bcs is like having an energy shot as supposed to slow consumption of same amount of caffeine
I have been the 450 xl and am having terrible headaches. I have been on it for over a year and just started having headaches anybody else run into this problem. I do have a history of migraines.
I’ve been taking Bupropion XL 150mg 1 x d for the past 3 weeks now and I noticed I am gaining a lot of weight especially around my waist. Does anyone have this experience and have switched to bupropion SR 100mg 2 x d instead and have lost weight?